|
KMID : 0358420090520040400
|
|
Korean Journal of Obstetrics and Gynecology
2009 Volume.52 No. 4 p.400 ~ p.406
|
|
|
Comparison of plasma Lipid and Lipoprotein concentrations in normal and intrauterine growth restriction pregnancies
|
|
Bae Jin-Gon
Park Joon-Cheol
Rhee Jeong-Ho
Kim Jong-In
|
|
|
Abstract
|
|
|
Objective: The effects of fetal growth of lipid metabolism in pregnancy are not well understood at present. The aim of this study was to perform a cross sectional study of lipid and lipidprotein concentrations in the 3rd trimester, from normal pregnancies and those complicated by intrauterine growth restriction pregnancies (IUGR) without preeclampsia.
Methods: Fasting blood samples for lipid and lipidprotein fractions were taken 3rd trimester. from fourty two women with IUGR; fourty five women with uncomplicated pregnancies matched as a group for age, parity, gestational age and fetal body weight.
Results: Total cholesterol (6.74±1.14 mmol/L vs 4.23±1.03 mmol/L, P<0.01), triglyceride 2.10±0.95 mmol/L vs 2.42±0.73 mmol/L. P<0.05) and LDL (3.41±0.83 mmol/L vs 4.23±1.07 mmol/L, P<0.01) concentrations were significantly lower in the IUGR group than in normal group. Free fatty acid (0.8±0.21 mmol/L vs 0.5±0.01 mmol/L, P<0.01) concentration, ApoB/ApoA ratio (0.86 ±0.42 vs 0.77±0.47, P<0.01). HDL/ApoA (0.87±0.1 vs 0.72±0.05, P<0.05) ratio were significantly higher in the IUGR group than in normal group. There were no difference in other lipids.
Conclusion: The results of this study suggest that LDL levels, which normally increase in uncomplicated pregnancies, fail to rise appropriately in pregnancies complicated by IUGR and may play a role in the pathogenesis of fetal growth restriction. Change in ApoA and increased ApoB/ApoA ratio may be used in identifying mothers with, or at risk of, a pregnancy complicated by IUGR.
|
|
|
KEYWORD
|
|
|
Lipid and Lipoprotein concentrations, Intrauterine growth restriction pregnancy
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|
|